Article
Molecular Characterization and Sterol Profiles Identify Nonsynonymous Mutations in ERG2 as a Major Mechanism Conferring Reduced Susceptibility to Amphotericin B in Candida kefyr.
Microbiology spectrum - 17 Aug 2023
Asadzadeh Mohammad, Alfouzan Wadha, Parker Josie E, Meis Jacques F, Kelly Steven L, Joseph Leena, Ahmad Suhail
Abstract excerpt
The molecular basis of reduced susceptibility to amphotericin B (rs-AMB) among any yeasts is poorly defined. Genetic alterations in genes involved in ergosterol biosynthesis and total cell sterols were investigated among clinical Candida kefyr isolates. C. kefyr isolates (n = 81) obtained from 74 patients in Kuwait and identified by phenotypic and molecular methods were analyzed. An Etest was initially used to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.