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Article

Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae.

Antimicrobial agents and chemotherapy - 1 Sept 2003

Young Laura Y, Hull Christina M, Heitman Joseph

Abstract excerpt

Candida lusitaniae is an emerging human pathogen that, unlike other fungal pathogens, frequently develops resistance to the commonly used antifungal agent amphotericin B. Amphotericin B is a member of the polyene class of antifungal drugs, which impair fungal cell membrane integrity. Here we analyzed mechanisms contributing to amphotericin B resistance in C. lusitaniae. Sensitivity to polyenes in the related...

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Source

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Identifiers

PMID: 12936965
DOI: 10.1128/AAC.47.9.2717-2724.2003
PMCID: PMC182600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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