Article
Acquired amphotericin B resistance attributed to a mutated ERG3 in Candidozyma auris.
Antimicrobial agents and chemotherapy - 5 Nov 2025
Massic Lauryn, Doorley Laura A, Jones Sarah J, Richardson Irene, Siao Danielle Denise, Siao Lauren, Dykema Philip, Hua Chi, Schneider Emily, Cuomo Christina A, Rogers P David, Van Hooser Stephanie, Parker Josie E, Kelly Steven L, Hess David, Rybak Jeffrey M, Pandori Mark
Abstract excerpt
First identified in 2009, Candidozyma auris (formerly Candida auris) is an emerging multidrug-resistant fungus that can cause invasive infections with a crude mortality rate ranging from 30 to 60%. Currently, 30-50% of C. auris isolates are intrinsically resistant to amphotericin B. In this study, we characterized a clinical case of acquired amphotericin B resistance using whole-genome sequencing, a large-scale...
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