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Article

The molecular underpinnings of female predominance in lupus.

Trends in molecular medicine - 1 May 2025

Kosmara Despoina, Neofotistou-Themeli Elpida, Semitekolou Maria, Bertsias George

Abstract excerpt

Most people affected by systemic lupus erythematosus (SLE) are women. Although the role of sex hormones has been appreciated, we discuss emerging evidence that links X-linked genes escaping from dosage compensation to female predisposition to lupus. This is exemplified by TLR7 and CXorf21 whose female-biased expression may converge to enhance interferon responses and promote autoantibody-producing B cells, which...

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Share to Epigenesis, Genetic
Share to TLR7 gene
Share to Genes, X-Linked

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Lupus Erythematosus, Systemic

Share to Sex Factors

Share to Toll-Like Receptor 7

Share to X Chromosome Inactivation

Source

Identifiers

PMID: 39627079
DOI: 10.1016/j.molmed.2024.11.002

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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