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Article

The Inactive X Chromosome: A Genetic Driver of Female-Biased Rheumatic Autoimmune Disorders?

European journal of immunology - 1 May 2025

Ferrayé Léa, Nieucel Mélissa, Savignac Magali, Chaumeil Julie, Guéry Jean-Charles

Abstract excerpt

Females have a better ability to resolve infections compared to males, but also a greater susceptibility to develop autoimmunity. Besides the initial interest in the contribution of sex-steroid hormone signaling, the role of genetic factors linked to the X chromosome has recently received much attention. In humans and mice, the number of X chromosomes, rather than sex-steroid hormones, is associated with a higher...

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Identifiers

PMID: 40417978
DOI: 10.1002/eji.202451331
PMCID: PMC12105428

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