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Article

Familial Parkinson’s point mutation abolishes multiple system atrophy prion replication

26 Dec 2017

Abstract excerpt

In the neurodegenerative disease multiple system atrophy (MSA), α-synuclein misfolds into a self-templating conformation to become a prion. To compare the biological activity of α-synuclein prions in MSA and Parkinson's disease (PD), we developed nine α-synuclein-YFP cell lines expressing point mutations responsible for inherited PD. MSA prions robustly infected wild-type, A30P, and A53T α-synuclein-YFP cells,...

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PMID: 29279394
DOI: 10.1073/pnas.1719369115

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