Article
SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity.
Molecular cell - 6 Jan 2022
Sheban Daoud, Shani Tom, Maor Roey, Aguilera-Castrejon Alejandro, Mor Nofar, Oldak Bernardo, Shmueli Merav D, Eisenberg-Lerner Avital, Bayerl Jonathan, Hebert Jakob, Viukov Sergey, Chen Guoyun, Kacen Assaf, Krupalnik Vladislav, Chugaeva Valeriya, Tarazi Shadi, Rodríguez-delaRosa Alejandra, Zerbib Mirie, Ulman Adi, Masarwi Solaiman, Kupervaser Meital, Levin Yishai, Shema Efrat, David Yael, Novershtern Noa, Hanna Jacob H, Merbl Yifat
Abstract excerpt
The fidelity of the early embryonic program is underlined by tight regulation of the chromatin. Yet, how the chromatin is organized to prohibit the reversal of the developmental program remains unclear. Specifically, the totipotency-to-pluripotency transition marks one of the most dramatic events to the chromatin, and yet, the nature of histone alterations underlying this process is incompletely characterized....
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