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H3K9 tri-methylation at <i>Nanog</i> times differentiation commitment and enables the acquisition of primitive endoderm fate

2021-06-22

Abstract excerpt

Mouse Embryonic Stem (ES) cells have an inherent propensity to explore distinct gene-regulatory states associated with either self-renewal or differentiation. This property is largely dependent on ERK activity, which promotes silencing of pluripotency genes, most notably of the transcription factor Nanog . Here, we aimed at identifying repressive histone modifications that would mark the Nanog locus for inactiva...

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Identifiers and source

Literature Corpus work
5fd8a083-aadc-5aee-b42c-43317ac8cf0d
DOI
10.1101/2021.06.22.449256
Open publication

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H3K9 tri-methylation at <i>Nanog</i> times differentiation commitment and enables the acquisition of primitive endoderm fateDOI 10.1101/2021.06.22.449256
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