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TET3 protects the Dlk1-Dio3 Imprinted Locus from DNA hypomethylation during adult NSC Reprogramming

2025-02-18

Abstract excerpt

Genomic imprinting is an epigenetic mechanism that drives monoallelic gene expression depending on parental origin. Loss of imprinting (LOI) is associated with human imprinting disorders, fetal development, and cancer progression. Imprinted genes, organized in clusters, are regulated by methylation at imprint control regions (ICRs), differentially methylated regions (DMRs) between parental chromosomes. Somatic cel...

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Literature Corpus work
4a1b5faa-7635-5d9b-8ddf-6b3712d01af6
DOI
10.1101/2025.02.13.638077
Open publication

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TET3 protects the Dlk1-Dio3 Imprinted Locus from DNA hypomethylation during adult NSC ReprogrammingDOI 10.1101/2025.02.13.638077
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