Article

NOTCH1 Acts as a Tumor Suppressor That Induces Early Differentiation in Head and Neck Cancer

2025-04-29

Abstract excerpt

<h4>ABSTRACT</h4> We identified frequent inactivating notch1 mutations in HNSCC over a decade ago, indicating its role as a tumor suppressor—unlike its oncogenic function in leukemias and salivary gland tumors. However, there has been much debate in the literature regarding a possible oncogenic role in HNSCC as well, based on reports that notch1 signaling drives tumor growth and a cancer stem cell phenotype in so...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f26408fc-0b41-5bd8-95eb-845e38da559e
DOI: 10.1101/2025.04.25.650710

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NOTCH1 Acts as a Tumor Suppressor That Induces Early Differentiation in Head and Neck CancerDOI 10.1101/2025.04.25.650710Read

NOTCH1 acts as a tumor suppressor that induces early differentiation in head and neck cancer.Semantic proximity Read

NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma.Semantic proximity Read

The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma.Semantic proximity Read

Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer.Semantic proximity Read

Activation of the NOTCH pathway in head and neck cancer.Semantic proximity Read

NOTCH mutations: multiple faces in human malignancies.Semantic proximity Read

The opposing roles of NOTCH signalling in head and neck cancer: a mini review.Semantic proximity Read

Notch1 mutations are drivers of oral tumorigenesis.Semantic proximity Read

Notch signaling pathway in cancer: from mechanistic insights to targeted therapiesSemantic proximity Read

Targeting cancer stem cells in squamous cell carcinomaSemantic proximity Read

HEY1 is expressed independent of NOTCH1 and is associated with poor prognosis in head and neck squamous cell carcinoma.Semantic proximity Read

The Cancer Stem Cell Concept in Progression of Head and Neck CancerSemantic proximity Read