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Article

HEY1 is expressed independent of NOTCH1 and is associated with poor prognosis in head and neck squamous cell carcinoma.

Oral oncology - 1 Jul 2018

Rettig Eleni M, Bishop Justin A, Agrawal Nishant, Chung Christine H, Sharma Rajni, Zamuner Fernando, Li Ryan J, Koch Wayne M, Califano Joseph A, Guo Theresa, Gaykalova Daria A, Fakhry Carole

Abstract excerpt

OBJECTIVES: Notch signaling is frequently altered in head and neck squamous cell carcinoma (HNSCC). However, the nature and clinical implications of this dysregulation are not well understood. We previously described an association of transcriptionally active NOTCH1 Intracellular Domain (NICD1) immunohistochemical (IHC) expression pattern with high-risk pathologic characteristics. Here we further characterize...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29909892
DOI: 10.1016/j.oraloncology.2018.05.017

Genes

NOTCH1
HEY1
JAG1

Provenance

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