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Article

The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma.

Journal of dental research - 1 Jun 2018

Fukusumi T, Califano J A

Abstract excerpt

Comprehensive genomic analyses have been performed for head and neck squamous cell carcinoma (HNSCC), revealing a significant rate of NOTCH1 mutations and identifying NOTCH1 as the second most frequently mutated gene after TP53. Most NOTCH1 mutations are considered inactivating, indicating that NOTCH1 is a tumor suppressor gene. On the other hand, cohorts from Asian populations with HNSCC have shown activating...

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Topics

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Share to Carcinoma, Squamous Cell
Share to NOTCH1 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29489439
DOI: 10.1177/0022034518760297
PMCID: PMC5960881

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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