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Article

The opposing roles of NOTCH signalling in head and neck cancer: a mini review.

Oral diseases - 1 Oct 2015

Yap L F, Lee D, Khairuddin Anm, Pairan M F, Puspita B, Siar C H, Paterson I C

Abstract excerpt

NOTCH signalling can exert oncogenic or tumour suppressive effects in both solid and haematological malignancies. Similar to T-cell acute lymphoblastic leukaemia (T-ALL), early studies suggested a pro-tumorigenic role of NOTCH in head and neck squamous cell carcinoma (HNSCC), mainly based on the increased expression levels of the genes within the pathway. Recently, data from exome sequencing analyses unexpectedly...

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Share to Carcinoma, Squamous Cell
Share to NOTCH1 gene
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

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Share to Receptors, Notch

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Source

Identifiers

PMID: 25580884
DOI: 10.1111/odi.12309

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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