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Article

The opposing roles of NOTCH signalling in head and neck cancer: a mini review.

Oral diseases - 1 Oct 2015

Yap L F, Lee D, Khairuddin Anm, Pairan M F, Puspita B, Siar C H, Paterson I C

Abstract excerpt

NOTCH signalling can exert oncogenic or tumour suppressive effects in both solid and haematological malignancies. Similar to T-cell acute lymphoblastic leukaemia (T-ALL), early studies suggested a pro-tumorigenic role of NOTCH in head and neck squamous cell carcinoma (HNSCC), mainly based on the...

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Share to Carcinoma, Squamous Cell
Share to NOTCH1 gene
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

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Share to Receptors, Notch

Share to Signal Transduction

Source

Identifiers

PMID: 25580884
DOI: 10.1111/odi.12309

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25580884-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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