Article
Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer.
Oncotarget - 2 Aug 2016
Upadhyay Pawan, Nair Sudhir, Kaur Ekjot, Aich Jyotirmoi, Dani Prachi, Sethunath Vidyalakshmi, Gardi Nilesh, Chandrani Pratik, Godbole Mukul, Sonawane Kavita, Prasad Ratnam, Kannan Sadhana, Agarwal Beamon, Kane Shubhada, Gupta Sudeep, Dutt Shilpee, Dutt Amit
Abstract excerpt
BACKGROUND: Notch pathway plays a complex role depending on cellular contexts: promotes stem cell maintenance or induces terminal differentiation in potential cancer-initiating cells; acts as an oncogene in lymphocytes and mammary tissue or plays a growth-suppressive role in leukemia, liver, skin, and head and neck cancer. Here, we present a novel clinical and functional significance of NOTCH1 alterations in...
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