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Article

NOTCH mutations: multiple faces in human malignancies.

Cancer prevention research (Philadelphia, Pa.) - 1 Apr 2015

Mao Li

Abstract excerpt

NOTCH proteins have been implicated in multiple cellular functions, such as stem cell maintenance and cell fate determination. Initially identified as proto-oncogenes because they promote the development of certain types of leukemia, inactivating mutations of NOTCH were later reported. Together with the potential distinct functions of NOTCH family members, their ligands and associated niches, the precise roles of...

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Share to Carcinoma, Squamous Cell
Share to Cell Transformation, Neoplastic
Share to NOTCH1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25712049
DOI: 10.1158/1940-6207.CAPR-15-0063

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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