NOTCH1 acts as a tumor suppressor that induces early differentiation in head and neck cancer.

doi:10.1172/jci.insight.202414

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Article

NOTCH1 acts as a tumor suppressor that induces early differentiation in head and neck cancer.

JCI insight - 8 Jun 2026

Huang Chenfei, Moorthy Shhyam, Li Qiuli, Ahmed Kazi M, Saab Kalil, Deng Defeng, Wang Jiping, Rao Xiayu, Zhang Jiexin, Xi Yuanxin, Wang Jing, Liu Zhiyi, Tanaka Noriaki, Wheeler David A, Shinbrot Eve, Saade Rami, Pickering Curtis R, Xie Tong-Xin, El-Naggar Adel K, Osman Abdullah A, Rai Kunal, Zweidler-McKay Patrick A, Heymach John V, Byers Lauren A, Johnson Faye M, Sandulache Vlad C, Myers Jeffrey N, Yadollahi Pedram, Frederick Mitchell J

Abstract excerpt

Inactivating NOTCH1 mutations in head and neck squamous cell carcinoma (HNSCC) were described over a decade ago, suggesting a tumor suppressor function - unlike its oncogenic role in other tumors. Today, much debate persists regarding a putative oncogenic role in HNSCC as well, with reports that NOTCH1 signaling drives tumor growth and a cancer stem cell (CSC) phenotype. In this work, comprehensive experiments...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Tumor Suppressor

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Source

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Identifiers

PMID: 41989846
DOI: 10.1172/jci.insight.202414

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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