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Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

27 May 2024

Abstract excerpt

Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution. The Notch receptor and its ligands are transmembrane proteins containing epidermal growth factor-like repeat sequences, typically necessitating receptor-ligand interaction to initiate classical Notch signaling transduction. Accumulating evidence...

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PMID: 38797752
DOI: 10.1038/s41392-024-01828-x

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