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Article

NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma.

Cells - 12 Dec 2020

Shah Pooja A, Huang Chenfei, Li Qiuli, Kazi Sawad A, Byers Lauren A, Wang Jing, Johnson Faye M, Frederick Mitchell J

Abstract excerpt

Biomarker-driven targeted therapies are lacking for head and neck squamous cell carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are hindered by a genomic landscape dominated by the loss of tumor suppressor function, including NOTCH1 that is frequently mutated in HNSCC. Clearer understanding of NOTCH1 signaling in HNSCCs is crucial to clinically targeting this pathway. Structural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33322834
DOI: 10.3390/cells9122677
PMCID: PMC7764697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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