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Article

Notch1 mutations are drivers of oral tumorigenesis.

Cancer prevention research (Philadelphia, Pa.) - 1 Apr 2015

Izumchenko Evgeny, Sun Kai, Jones Sian, Brait Mariana, Agrawal Nishant, Koch Wayne, McCord Christine L, Riley David R, Angiuoli Samuel V, Velculescu Victor E, Jiang Wei-Wen, Sidransky David

Abstract excerpt

Disruption of NOTCH1 signaling was recently discovered in head and neck cancer. This study aims to evaluate NOTCH1 alterations in the progression of oral squamous cell carcinoma (OSCC) and compare the occurrence of these mutations in Chinese and Caucasian populations. We used a high-throughput PCR-based enrichment technology and next-generation sequencing (NGS) to sequence NOTCH1 in 144 samples collected in...

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Share to Carcinoma, Squamous Cell
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukoplakia, Oral

Share to Mouth Mucosa

Share to Mouth Neoplasms

Share to Receptor, Notch1

Source

Open in PubMed Open full text

Identifiers

PMID: 25406187
DOI: 10.1158/1940-6207.CAPR-14-0257
PMCID: PMC4383685

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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