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Article

Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model

8 Nov 2019

Abstract excerpt

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. The major AF susceptibility locus 4q25 establishes long-range interactions with the promoter of PITX2 , a transcription factor gene with critical functions during cardiac development. While many AF-linked loci have been identified in genome-wide association studies, mechanistic understanding into how genetic variants, including those at the...

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PMID: 31704768
DOI: 10.1073/pnas.1913905116

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