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Article

<i>PITX2</i> Insufficiency Leads to Atrial Electrical and Structural Remodeling Linked to Arrhythmogenesis

22 Apr 2011

Abstract excerpt

BACKGROUND: Pitx2 is a homeobox transcription factor that plays a pivotal role in early left/right determination during embryonic development. Pitx2 loss-of-function mouse mutants display early embryonic lethality with severe cardiac malformations, demonstrating the importance of Pitx2 during cardiogenesis. Recently, independent genome-wide association studies have provided new evidence for a putative role of...

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Identifiers

PMID: 21511879
DOI: 10.1161/circgenetics.110.958116

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<i>PITX2</i> Insufficiency Leads to Atrial Electrical and Structural Remodeling Linked to ArrhythmogenesisPMID 21511879Read ↗

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