Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In silico investigation of the mechanisms underlying atrial fibrillation due to impaired Pitx2.

PLoS computational biology - 1 Feb 2020

Bai Jieyun, Lo Andy, Gladding Patrick A, Stiles Martin K, Fedorov Vadim V, Zhao Jichao

Abstract excerpt

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is a major cause of stroke and morbidity. Recent genome-wide association studies have shown that paired-like homeodomain transcription factor 2 (Pitx2) to be strongly associated with AF. However, the mechanisms underlying Pitx2 modulated arrhythmogenesis and variable effectiveness of antiarrhythmic drugs (AADs) in patients in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Arrhythmia Agents
Share to Atrial Fibrillation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flecainide

Share to Heart Atria

Share to Homeobox Protein PITX2

Share to Ryanodine Receptor Calcium Release Channel

Share to Sarcoplasmic Reticulum

Share to Sodium

Source

Open in PubMed Open full text

Identifiers

PMID: 32097431
DOI: 10.1371/journal.pcbi.1007678
PMCID: PMC7059955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In silico investigation of the mechanisms underlying atrial fibrillation due to impaired Pitx2.PMID 32097431Read ↗

Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models.Semantic proximity Read ↗

Understanding PITX2-dependent Atrial Fibrillation Mechanisms through Computational ModelsSemantic proximity Read ↗

In Silico Assessment of Class I Antiarrhythmic Drugs Effects on Pitx2-induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and TissuesSemantic proximity Read ↗

In Silico Assessment of Genetic Variation in PITX2 Reveals the Molecular Mechanisms of Calcium-Mediated Cellular Triggered Activity in Atrial Fibrillation.Semantic proximity Read ↗

PITX2-dependent gene regulation in atrial fibrillation and rhythm control.Semantic proximity Read ↗

Modulation of conductive elements by Pitx2 and their impact on atrial arrhythmogenesis.Semantic proximity Read ↗

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.Semantic proximity Read ↗

Pitx2 impairs calcium handling in a dose-dependent manner by modulating Wnt signallingSemantic proximity Read ↗

PITX2c Is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene ExpressionSemantic proximity Read ↗

PITX2C Deficiency Promotes Arrhythmogenic Remodeling via Oxidative Stress in Atrial MyocytesSemantic proximity Read ↗

<i>PITX2</i> Insufficiency Leads to Atrial Electrical and Structural Remodeling Linked to ArrhythmogenesisSemantic proximity Read ↗

Nox4 Mediates Diastolic Function in a Genetic Model of Pitx2 HaploinsufficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.