Article

Ventricular chamber-specific Pitx2 insufficiency leads to cardiac hypertrophy and arrhythmias

2018-01-26

Abstract excerpt

Genome-wide association studies (GWAS) have identified genetic risk variant adjacent to the homeobox transcription factor PITX2 in atrial fibrillation (AF) patients. Experimental studies demonstrated that Pitx2 insufficiency leads to cellular and molecular substrates that increased atrial arrhythmias susceptibility. Pitx2 expression is present not only in the atrial but also in the ventricular myocytes. This study...

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Literature Corpus work: 2a625a5d-0b90-589c-bf5e-1d80bf8fead5
DOI: 10.1101/253062

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