Article

Nox4 Mediates Diastolic Function in a Genetic Model of Pitx2 Haploinsufficiency

2026-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Heart failure with preserved ejection fraction (HFpEF) commonly coexists with atrial fibrillation (AF), but shared mechanisms remain unclear. In this study, we hypothesized that Pitx2 , a transcription factor located near the strongest genetic locus associated with AF in humans, increases susceptibility to HFpEF-like remodeling. We also sought to understand pathways that might be central to thi...

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Literature Corpus work: 8b6cd2ca-119d-561c-abe6-9ce28bad8569
DOI: 10.64898/2026.06.30.735639

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