Article
Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.
Science translational medicine - 31 Aug 2016
Nadadur Rangarajan D, Broman Michael T, Boukens Bastiaan, Mazurek Stefan R, Yang Xinan, van den Boogaard Malou, Bekeny Jenna, Gadek Margaret, Ward Tarsha, Zhang Min, Qiao Yun, Martin James F, Seidman Christine E, Seidman Jon, Christoffels Vincent, Efimov Igor R, McNally Elizabeth M, Weber Christopher R, Moskowitz Ivan P
Abstract excerpt
Cardiac rhythm is extremely robust, generating 2 billion contraction cycles during the average human life span. Transcriptional control of cardiac rhythm is poorly understood. We found that removal of the transcription factor gene Tbx5 from the adult mouse caused primary spontaneous and sustained atrial fibrillation (AF). Atrial cardiomyocytes from the Tbx5-mutant mice exhibited action potential abnormalities,...
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