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Article

Modulation of conductive elements by Pitx2 and their impact on atrial arrhythmogenesis.

Cardiovascular research - 15 Jul 2011

Franco Diego, Chinchilla Ana, Daimi Houria, Dominguez Jorge N, Aránega Amelia

Abstract excerpt

The development of the heart is a complex process during which different cell types progressively contribute to shape a four-chambered pumping organ. Over the last decades, our understanding of the specification and transcriptional regulation of cardiac development has been greatly augmented as has our understanding of the functional bases of cardiac electrophysiology during embryogenesis. The nascent heart...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21427120
DOI: 10.1093/cvr/cvr078

Genes

PITX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modulation of conductive elements by Pitx2 and their impact on atrial arrhythmogenesis.PMID 21427120Read ↗

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<i>PITX2</i> Insufficiency Leads to Atrial Electrical and Structural Remodeling Linked to ArrhythmogenesisSemantic proximity Read ↗

PITX2-dependent gene regulation in atrial fibrillation and rhythm control.Semantic proximity Read ↗

<i>Pitx2</i> , an Atrial Fibrillation Predisposition Gene, Directly Regulates Ion Transport and Intercalated Disc GenesSemantic proximity Read ↗

Ventricular chamber-specific Pitx2 insufficiency leads to cardiac hypertrophy and arrhythmiasSemantic proximity Read ↗

<i>Pitx2</i> prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specificationSemantic proximity Read ↗

PITX2c Is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene ExpressionSemantic proximity Read ↗

Understanding PITX2-dependent Atrial Fibrillation Mechanisms through Computational ModelsSemantic proximity Read ↗

Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models.Semantic proximity Read ↗

Regulation of cardiac ion channels by transcription factors: Looking for new opportunities of druggable targets for the treatment of arrhythmiasSemantic proximity Read ↗

Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.Semantic proximity Read ↗

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