Article
Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer.
International journal of cancer - 1 Mar 2023
Carm Kristina T, Johannessen Bjarne, Bogaard Mari, Bakken Anne Cathrine, Maltau Aase V, Hoff Andreas M, Axcrona Ulrika, Axcrona Karol, Lothe Ragnhild A, Skotheim Rolf I
Abstract excerpt
Primary prostate cancer shows a striking intraorgan molecular heterogeneity, with multiple spatially separated malignant foci in the majority of patients. Metastatic prostate cancer, however, typically reveals more homogenous molecular profiles, suggesting a monoclonal origin of the metastatic lesions. Longitudinal mutational spectra, comparing multiple primary lesions with metastases from the same patients...
Topics
- Male
- Humans
- Mutation
- Genomics
- Prostatic Neoplasms
- Circulating Tumor DNA