Article
Patterns of intra- and intertumor phenotypic heterogeneity in lethal prostate cancer.
The Journal of clinical investigation - 1 Aug 2025
Roudier Martine P, Gulati Roman, Sayar Erolcan, Patel Radhika A, Tratt Micah, Richards Helen M, Cejas Paloma, Munoz Gomez Miguel, Qiu Xintao, Xie Yingtian, Hanratty Brian, Zaidi Samir, Zhao Jimmy L, Adil Mohamed, Mittal Chitvan, Zhao Yibai, Dumpit Ruth, Coleman Ilsa, Low Jin-Yih, Persse Thomas, Galipeau Patricia, Lee John K, Tretiakova Maria, Chambers Meagan, Vakar-Lopez Funda, True Lawrence D, Perrone Marie, Lam Hung-Ming, Kollath Lori A, Ding Chien-Kuang Cornelia, Harmon Stephanie, Cheng Heather H, Yu Evan Y, Montgomery Robert B, Hawley Jessica E, Lin Daniel W, Corey Eva, Schweizer Michael T, Setty Manu, Ha Gavin, Sawyers Charles L, Morrissey Colm, Long Henry, Nelson Peter S, Haffner Michael C
Abstract excerpt
Metastatic prostate cancer (mPC) is a clinically and molecularly heterogeneous disease. While there is increasing recognition of diverse tumor phenotypes across patients, less is known about the molecular and phenotypic heterogeneity present within an individual. In this study, we aimed to define the patterns, extent, and consequences of inter- and intratumoral heterogeneity in lethal prostate cancer. By...
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