Translational and clinical implications of the genetic landscape of prostate cancer.

doi:10.1038/nrclinonc.2016.76

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Article

Translational and clinical implications of the genetic landscape of prostate cancer.

Nature reviews. Clinical oncology - 1 Oct 2016

Spratt Daniel E, Zumsteg Zachary S, Feng Felix Y, Tomlins Scott A

Abstract excerpt

Over the past several years, analyses of data from high-throughput studies have elucidated many fundamental insights into prostate cancer biology. These insights include the identification of molecular alterations and subtypes that drive tumour progression, recurrent aberrations in signalling pathways, the existence of substantial intertumoural and intratumoural heterogeneity, Darwinian evolution in response to...

Topics

Androgens
Cell Cycle
Cell Proliferation
DNA Damage
DNA Repair
Disease Progression
Drug Resistance, Neoplasm
Gene Expression Profiling
Genetic Heterogeneity
Genetic Predisposition to Disease
Genomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Isocitrate Dehydrogenase

MAP Kinase Signaling System

Male

Neuroendocrine Tumors

Prostatic Neoplasms

Receptors, Androgen

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Identifiers

PMID: 27245282
DOI: 10.1038/nrclinonc.2016.76
PMCID: PMC5030163

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