Multiregion sampling of de novo metastatic prostate cancer reveals complex polyclonality and augments clinical genotyping.

doi:10.1038/s43018-023-00692-y

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Article

Multiregion sampling of de novo metastatic prostate cancer reveals complex polyclonality and augments clinical genotyping.

Nature cancer - 1 Jan 2024

Warner Evan W, Van der Eecken Kim, Murtha Andrew J, Kwan Edmond M, Herberts Cameron, Sipola Joonatan, Ng Sarah W S, Chen Xinyi E, Fonseca Nicolette M, Ritch Elie, Schönlau Elena, Bernales Cecily Q, Donnellan Gráinne, Munzur Aslı D, Parekh Karan, Beja Kevin, Wong Amanda, Verbeke Sofie, Lumen Nicolaas, Van Dorpe Jo, De Laere Bram, Annala Matti, Vandekerkhove Gillian, Ost Piet, Wyatt Alexander W

Abstract excerpt

De novo metastatic prostate cancer is highly aggressive, but the paucity of routinely collected tissue has hindered genomic stratification and precision oncology. Here, we leveraged a rare study of surgical intervention in 43 de novo metastatic prostate cancers to assess somatic genotypes across 607 synchronous primary and metastatic tissue regions plus circulating tumor DNA. Intra-prostate heterogeneity was...

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PMID: 38177459
DOI: 10.1038/s43018-023-00692-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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