Article
Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer.
Nature genetics - 1 Sept 2026
Shiba Satoshi, Yachida Shinichi, Mizutani Sayaka, Totoki Yasushi, Nakamura Hiromi, Hama Natsuko, Miyoshi Norikatsu, Arai Yasuhito, Saito-Adachi Mihoko, Kimura Hirokazu, Hayashi Yoshito, Takamaru Hiroyuki, Tanaka Koji, Hayashi Rie, Rokutan Hirofumi, Ikuta Shoko, Kanemitsu Yukihide, Doki Yuichiro, Eguchi Hidetoshi, Hattori Satoshi, Saito Yutaka, Yamada Takuji, Shibata Tatsuhiro
Abstract excerpt
The incidence of colorectal cancer (CRC) has risen in recent decades, with a disproportionate increase observed among younger individuals in Japan and other countries. The etiological contribution of the gut microbiota to CRC pathogenesis is recognized, yet the mechanisms involved remain to be fully clarified. Here we integrated whole-genome sequencing (WGS) and transcriptome profiling of CRC with whole-genome...
Read the complete abstract on PubMedTopics
- Humans
- Colorectal Neoplasms
- Japan
- Mutation