Lipid Nanoparticles for Spleen-Targeted RNA delivery

Abstract excerpt

Lipid nanoparticles (LNPs) formulated with neutral helper lipids efficiently deliver RNA to the liver in pre-clinical models and humans but achieving clinically relevant delivery to other tissues remains a major challenge. To reduce liver uptake, targeting strategies often range from active targeting relying on antibodies to quasi-active targeting by employing permanently charged helper lipids which influence biod...

Topics

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• Gene Transfer Techniques
• Genetic Variation
• Immunomodulation
• Leukocytes
• Lipids
• Nanoparticles
• RNA Interference and Gene Delivery
• RNA, Small Interfering

Identifiers and source

Literature Corpus work

0c22cca4-2d61-51af-a091-6c6a9809e16b

DOI

10.64898/2026.04.13.718229