Article

Engineering ionizable lipids for rapid biodegradation balances mRNA vaccine efficacy and tolerability

2024-08-03

Abstract excerpt

The optimization of lipid nanoparticles (LNPs) has played a key role in enhancing the efficacy of mRNA vaccines, yet challenges with LNP tolerability remain. The ionizable lipid component within LNPs is critical to the efficient delivery of mRNA. Ionizable lipids can also trigger innate immune activation, which is beneficial for vaccine efficacy but may contribute to adverse inflammatory reactions. Engineering ion...

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Literature Corpus work: 45052de6-9205-5fc6-81b3-63a161f291cd
DOI: 10.1101/2024.08.02.606386

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