Article

Engineering age-adaptive mRNA lipid nanoparticle cancer vaccines via reprogramming systemic gene expression

2026-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Lipid nanoparticle (LNP)–based mRNA vaccines have transformed cancer immunotherapy, yet their efficacy in older individuals, who represent the majority of cancer patients, remains poorly understood. Here, we uncover a critical and previously underappreciated barrier to mRNA LNP cancer vaccine performance in aged hosts: impaired systemic transgene expression. Using the SM-102 mRNA LNPs as a bench...

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Literature Corpus work: 162c74f5-13ba-5d62-803d-b2ae03bcfe85
DOI: 10.64898/2026.04.11.717910

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