Article

Engineering of mRNA vaccine platform with reduced lipids and enhanced efficacy

2024-08-08

Abstract excerpt

<title>Abstract</title> <p>Lipid nanoparticles (LNPs) are the most clinically relevant vehicles for mRNA vaccines. Despite the great successes, the toxicity caused by the high dose of lipid components still represents a great challenge. The suboptimal loading efficiency of mRNA in LNPs not only compromises the vaccine’s efficacy but also heightens the risk of non-specific immune responses, accelerates clearance f...

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Literature Corpus work: 51bb3389-14e4-5667-830a-05b39a94864e
DOI: 10.21203/rs.3.rs-4755456/v1

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