Article

Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced <i>In vivo</i> mRNA Delivery

2024-12-30

Abstract excerpt

Therapies based on mRNA technology have offered hope to millions of patients worldwide by disrupting the way we treat diseases. The safe and functional delivery of the delicate mRNA molecules to the target tissue is a crucial step in the development of effective vaccines and therapeutic interventions. Lipid nanoparticles (LNP) are the most clinically advanced delivery vehicles for mRNA drugs. Key to the success of...

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Literature Corpus work: 3d788b39-0148-5a03-9951-b80fa9ac1b4b
DOI: 10.1101/2024.12.30.630759

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