Article

A modular mRNA–LNP vaccine platform enables integrated RNA, lipid and antigen design to protect against CCHFV

2026-01-18

Abstract excerpt

mRNA–lipid nanoparticle (LNP) vaccines are programmable, multi-component systems in which immune outcomes emerge from coupled control of nanoparticle chemistry, RNA regulatory architecture, and antigen design. Here we establish an integrated engineering framework that quantitatively maps how ionizable lipid identity, untranslated region (UTR) configuration, and 5′ cap structure shape innate activation landscapes a...

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Literature Corpus work: fb15200b-4738-5c17-873c-ec029ee76ac7
DOI: 10.64898/2026.01.17.699915

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