The mutational landscape of normal human endometrial epithelium.

doi:10.1038/s41586-020-2214-z

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Article

The mutational landscape of normal human endometrial epithelium.

Nature - 1 Apr 2020

Moore Luiza, Leongamornlert Daniel, Coorens Tim H H, Sanders Mathijs A, Ellis Peter, Dentro Stefan C, Dawson Kevin J, Butler Tim, Rahbari Raheleh, Mitchell Thomas J, Maura Francesco, Nangalia Jyoti, Tarpey Patrick S, Brunner Simon F, Lee-Six Henry, Hooks Yvette, Moody Sarah, Mahbubani Krishnaa T, Jimenez-Linan Mercedes, Brosens Jan J, Iacobuzio-Donahue Christine A, Martincorena Inigo, Saeb-Parsy Kourosh, Campbell Peter J, Stratton Michael R

Abstract excerpt

All normal somatic cells are thought to acquire mutations, but understanding of the rates, patterns, causes and consequences of somatic mutations in normal cells is limited. The uterine endometrium adopts multiple physiological states over a lifetime and is lined by a gland-forming epithelium1,2. Here, using whole-genome sequencing, we show that normal human endometrial glands are clonal cell populations with...

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PMID: 32350471
DOI: 10.1038/s41586-020-2214-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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