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Article

Whole-genome sequencing-based characterization of endometrial serous carcinoma.

Gynecologic oncology - 1 Oct 2025

Andres Sarah, Brown David N, Da Cruz Paula Arnaud, Aghajanian Carol, Abu-Rustum Nadeem R, Ellenson Lora H, Weigelt Britta

Abstract excerpt

OBJECTIVE: To define the structural variants, mutational signatures, and DNA repair defects in serous endometrial carcinoma (EC) using whole-genome sequencing (WGS). METHODS: Ten primary untreated classic serous ECs diagnosed between 2012 and 2018 were selected. Tumor and matched normal DNAs were subjected to WGS, and sequencing data were analyzed using state-of-the-art bioinformatics methods. RESULTS: All serous...

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Share to Cystadenocarcinoma, Serous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40848684
DOI: 10.1016/j.ygyno.2025.08.022
PMCID: PMC12648967

Genes

TP53
AKT2
CCNE1
FGA
PIK3CA
PPP2R1A

Provenance

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