Article
Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2013
Zhao Siming, Choi Murim, Overton John D, Bellone Stefania, Roque Dana M, Cocco Emiliano, Guzzo Federica, English Diana P, Varughese Joyce, Gasparrini Sara, Bortolomai Ileana, Buza Natalia, Hui Pei, Abu-Khalaf Maysa, Ravaggi Antonella, Bignotti Eliana, Bandiera Elisabetta, Romani Chiara, Todeschini Paola, Tassi Renata, Zanotti Laura, Carrara Luisa, Pecorelli Sergio, Silasi Dan-Arin, Ratner Elena, Azodi Masoud, Schwartz Peter E, Rutherford Thomas J, Stiegler Amy L, Mane Shrikant, Boggon Titus J, Schlessinger Joseph, Lifton Richard P, Santin Alessandro D
Abstract excerpt
Uterine serous carcinoma (USC) is a biologically aggressive subtype of endometrial cancer. We analyzed the mutational landscape of USC by whole-exome sequencing of 57 cancers, most of which were matched to normal DNA from the same patients. The distribution of the number of protein-altering somatic mutations revealed that 52 USC tumors had fewer than 100 (median 36), whereas 5 had more than 3,000 somatic...
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