Article

Polycomb Repressive Complex 2 is critical for mouse cortical glutamatergic neuron development

2023-11-05

Abstract excerpt

<h4>Summary</h4> The Polycomb Repressive Complex 2 (PRC2) regulates corticogenesis, yet the consequences of mutations to this epigenetic modifier in the mature brain are poorly defined. Importantly, PRC2 core genes are haploinsufficient and causative for several human neurodevelopmental disorders. To address the role of PRC2 in mature cortical structure and function, we conditionally mutated the PRC2 gene Eed in...

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Literature Corpus work: f210a82f-03e5-5621-b947-de91dcd83509
DOI: 10.1101/2023.11.05.565413

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