Article

Integrative multi-omics analyses reveal multi-modal FOXG1 functions acting on epigenetic processes and in concert with NEUROD1 to regulate synaptogenesis in the mouse hippocampus

2021-10-25

Abstract excerpt

<h4>Background</h4> FOXG1 has important functions for neuronal differentiation and balances excitatory/inhibitory network activity. Mutations in the human FOXG1 gene cause a rare neurodevelopmental disorder, FOXG1-syndrome, which manifests differing phenotypes, including severe cognitive dysfunction, microencephaly, social withdrawal, and communication and memory deficits. Changes at the molecular level underlyi...

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Literature Corpus work: a8168e31-6bf5-5e66-9e34-1eca60f53440
DOI: 10.1101/2021.10.25.465562

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