Article

Accounting for errors in data improves timing in single-cell cancer evolution

2021-03-19

Abstract excerpt

Single-cell sequencing provides a new way to explore the evolutionary history of cells. Compared to traditional bulk sequencing, where a population of heterogeneous cells is pooled to form a single observation, single-cell sequencing isolates and amplifies genetic material from individual cells, thereby preserving the information about the origin of the sequences. However, single-cell data is more error-prone than...

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Literature Corpus work: 42f660fe-4a66-53b2-968c-3db94a2b64b2
DOI: 10.1101/2021.03.17.435906

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