Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing.

Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2016

Jiang Yuchao, Qiu Yu, Minn Andy J, Zhang Nancy R

Abstract excerpt

Cancer is a disease driven by evolutionary selection on somatic genetic and epigenetic alterations. Here, we propose Canopy, a method for inferring the evolutionary phylogeny of a tumor using both somatic copy number alterations and single-nucleotide alterations from one or more samples derived from a single patient. Canopy is applied to bulk sequencing datasets of both longitudinal and spatial experimental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clonal Evolution
Share to Computational Biology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Genetic Heterogeneity

Share to High-Throughput Nucleotide Sequencing

Share to Internet

Share to Software

Source

Open in PubMed Open full text

Identifiers

PMID: 27573852
DOI: 10.1073/pnas.1522203113
PMCID: PMC5027458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing.PMID 27573852Read ↗

Reconstructing tumor clonal heterogeneity and evolutionary relationships based on tumor DNA sequencing data.Semantic proximity Read ↗

Phertilizer: Growing a clonal tree from ultra-low coverage single-cell DNA sequencing of tumorsSemantic proximity Read ↗

PHALCON: phylogeny-aware variant calling from large-scale single-cell panel sequencing datasetsSemantic proximity Read ↗

Pharming: Joint Clonal Tree Reconstruction of Single-Nucleotide Variant and Copy Number Aberration Evolution from Single-Cell DNA Sequencing of Tumors.Semantic proximity Read ↗

MuSE: accounting for tumor heterogeneity using a sample-specific error model improves sensitivity and specificity in mutation calling from sequencing data.Semantic proximity Read ↗

Pan-cancer evolution signatures link clonal expansion to dynamic changes in the tumor immune microenvironment.Semantic proximity Read ↗

Accurate detection of tumor clonality and ongoing expansion mode from genomic dataSemantic proximity Read ↗

Longitudinal Phylogenetic Inference of Copy Number Alterations and Single Nucleotide Variants from Single-Cell SequencingSemantic proximity Read ↗

Pharming: Joint Clonal Tree Reconstruction of SNV and CNA Evolution from Single-cell DNA Sequencing of TumorsSemantic proximity Read ↗

Tumour evolution as ground truth for cancer whole-genome sequencingSemantic proximity Read ↗

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data.Semantic proximity Read ↗

Bayesian inference for copy number intra-tumoral heterogeneity from single-cell RNA-sequencing dataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.