Article

An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequences

2023-02-16

Abstract excerpt

<title>Abstract</title> <p>T cell receptor repertoires can be profiled using next generation sequencing (NGS) to measure and monitor adaptive dynamical changes in response to disease and other perturbations. Genomic DNA-based bulk sequencing is cost-effective but necessitates multiplex target amplification using multiple primer pairs with highly variable amplification efficiencies. Here, we utilize an equimolar p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2032501-49df-5293-b53a-aa31dfb5c46d
DOI: 10.21203/rs.3.rs-2140339/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequencesDOI 10.21203/rs.3.rs-2140339/v1Read

An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequencesSemantic proximity Read

Next generation sequencing for TCR repertoire profiling: Platform‐specific features and correction algorithmsSemantic proximity Read

Systematic comparative study of computational methods for T-cell receptor sequencing data analysisSemantic proximity Read

Analysis of the Repertoire Features of TCR Beta Chain CDR3 in Human by High-Throughput Sequencing.Semantic proximity Read

TIRTL-seq: Deep, quantitative, and affordable paired TCR repertoire sequencingSemantic proximity Read

Systematic Comparative Evaluation of Methods for Investigating the TCRβ RepertoireSemantic proximity Read

VDJdive and ECLIPSE enhance single-cell TCR sequencing analysis through the probabilistic resolution of ambiguous clonotypesSemantic proximity Read

Rigorous benchmarking of T cell receptor repertoire profiling methods for cancer RNA sequencingSemantic proximity Read

IMSEQ—a fast and error aware approach to immunogenetic sequence analysisSemantic proximity Read

Rigorous benchmarking of T-cell receptor repertoire profiling methods for cancer RNA sequencingSemantic proximity Read

Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing.Semantic proximity Read

TCR Repertoire Analysis by Next Generation Sequencing Allows Complex Differential Diagnosis of T Cell–Related PathologySemantic proximity Read