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Systematic Comparative Evaluation of Methods for Investigating the TCRβ Repertoire

28 Mar 2016

Abstract excerpt

High-throughput sequencing has recently been applied to profile the high diversity of antibodyome/B cell receptors (BCRs) and T cell receptors (TCRs) among immune cells. To date, Multiplex PCR (MPCR) and 5'RACE are predominately used to enrich rearranged BCRs and TCRs. Both approaches have advantages and disadvantages; however, a systematic evaluation and direct comparison of them would benefit researchers in the...

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PMID: 27019362
DOI: 10.1371/journal.pone.0152464

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