Article

An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequences

2022-04-01

Abstract excerpt

<h4>ABSTRACT</h4> T cell receptor (TCR) repertoires can be profiled using next generation sequencing (NGS) to monitor dynamical changes in response to disease and other perturbations. Several strategies for profiling TCRs have been recently developed with different benefits and drawbacks. Genomic DNA-based bulk sequencing, however, remains the most cost-effective method to profile TCRs. The major disadvantage of...

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Literature Corpus work: 047928b8-9e08-5616-824f-d873371e2e3e
DOI: 10.1101/2022.03.30.486449

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