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MEDALT: single-cell copy number lineage tracing enabling gene discovery.

Genome biology - 23 Feb 2021

Wang Fang, Wang Qihan, Mohanty Vakul, Liang Shaoheng, Dou Jinzhuang, Han Jincheng, Minussi Darlan Conterno, Gao Ruli, Ding Li, Navin Nicholas, Chen Ken

Abstract excerpt

We present a Minimal Event Distance Aneuploidy Lineage Tree (MEDALT) algorithm that infers the evolution history of a cell population based on single-cell copy number (SCCN) profiles, and a statistical routine named lineage speciation analysis (LSA), whichty facilitates discovery of fitness-associated alterations and genes from SCCN lineage trees. MEDALT appears more accurate than phylogenetics approaches in...

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Identifiers

PMID: 33622385
DOI: 10.1186/s13059-021-02291-5
PMCID: PMC7901082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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