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Rapid and efficient generation of human 8-cell-like cells for embryo modelling

2026-08-19

Abstract excerpt

8-cell blastomeres of human embryos possess broad lineage potential and undergo major zygotic genome activation (ZGA), yet experimental access to this transient cell state remains limited. Rare 8-cell-like cells (8CLCs) arise spontaneously in naïve pluripotent stem cell cultures, but their low abundance has constrained mechanistic and functional studies. Here, we develop a chemically defined strategy for rapid and...

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Literature Corpus work
eaab7dea-7c06-598d-a555-a5ac8ee9101c
DOI
10.64898/2026.08.18.745473
Open publication

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Rapid and efficient generation of human 8-cell-like cells for embryo modellingDOI 10.64898/2026.08.18.745473
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