Article

A signalling rheostat controls chromosome segregation fidelity during early lineage specification and neurogenesis by modulating DNA replication stress

2023-07-18

Abstract excerpt

The development and homeostasis of organisms rely on the correct replication, maintenance and segregation of their genetic blueprints. How these intracellular processes are monitored across generations of different human cellular lineages, and why the spatio-temporal distribution of mosaicism varies during development remain unknown. Here, we identify several lineage specification signals that regulate chromosome...

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Literature Corpus work: 8ffd37ab-ec99-559b-bc3a-e3189b210361
DOI: 10.1101/2023.07.18.549463

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